Vertebrate Segmentation: Lunatic Transcriptional Regulation
نویسنده
چکیده
Vertebrate segmentation relies on a molecular oscillator, the segmentation clock, which controls the periodic expression of genes such as lunatic fringe in the presomitic mesoderm. Oscillations of lunatic fringe transcripts have now been shown to be controlled at the transcriptional level by clock elements in the lunatic fringe promoter.
منابع مشابه
Dynamic properties of the segmentation clock mediated by microRNA.
Somites are embryonic precursors that give rise to the axial skeleton and skeletal muscles and form the segmental vertebrate body plan. Somitogenesis is controlled by the "segmentation clock", which contains multiple oscillator genes that must be tightly regulated at both the transcriptional and post-transcriptional levels for proper clock function. However, how the segmentation clock governs t...
متن کاملVertebrate segmentation: The clock is linked to Notch signalling
The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.
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The most obvious segments of the vertebrate embryo are the trunk mesodermal somites which give rise to the segmented vertebral column and the skeletal muscles of the body. Mechanistic insights into vertebrate somitogenesis have recently been gained from observations of rhythmic expression of the avian hairy-related gene (c-hairy1) in chick presomitic mesoderm (PSM), suggesting the existence of ...
متن کاملSprouty4, an FGF Inhibitor, Displays Cyclic Gene Expression under the Control of the Notch Segmentation Clock in the Mouse PSM
BACKGROUND During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of components of the Notch, Wnt and FGF signaling pathways. PRINCIPAL FINDINGS Here, w...
متن کاملDifferential Axial Requirements for Lunatic Fringe and Hes7 Transcription during Mouse Somitogenesis
Vertebrate segmentation is regulated by the "segmentation clock", which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM). One such gene is Lunatic fringe (Lfng), which encodes a modifier of Notch signalling, and which is also expressed in a stripe at the cranial end of the PSM, adjacent to the newly forming somite border. We have investigated the functional requ...
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ورودعنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002